Retro-futuristic universe where John Wayne embodies an anime space cowboy, blending the gritty charm of a classic Western hero with the sleek aesthetic of Cowboy Bebop and Trigun; set against a backdrop of sprawling galaxy frontiers, vibrant nebulae, and lawless space outposts, he dons a rugged hat and a long duster coat, his trusty blaster at his hip, and a bandolier slung across his chest, exuding a calm, steely resolve as he navigates through the cosmos on a sleek, weathered spaceship, pursuing justice across the stars with a silent determination that echoes the wild frontier spirit of the old West in a high-tech, neon-lit future.